Publications
Here the publications produced by this project will be added continuously.
In bold are researchers from the SYNTRAIN Consortium
(17) Aleksandra Pettke, Marianna Tampere, Cristiano Salata, Olov Wallner, Tobias Koolmeister, Armando Cazares-Körner, Torkild Visnes, Maria Carmen Hesselman, Elena Kunold, Elisee Wiita, Christina Kalderén, Molly Lightowler, Ann-Sofie Jemth, Janne Lehtiö, Åsa Rosenquist, Ulrika Warpman-Berglund, Thomas Helleday, Ali Mirazimi, Rozbeh Jafari, Marjo-Riitta Puumalainen. Novel Broad-Spectrum Antiviral Inhibitors Targeting Host Factors Essential for Replication of Pathogenic RNA Viruses. Viruses 2020 Dec 10;12(12):1423.DOI: 10.3390/v12121423.
(16) Torkild Visnes, Carlos Benítez-Buelga, Armando Cázares-Körner, Kumar Sanjiv , Bishoy M F Hanna, Oliver Mortusewicz, Varshni Rajagopal, Julian J Albers, Daniel W Hagey, Tove Bekkhus, Saeed Eshtad, Juan Miguel Baquero , Geoffrey Masuyer, Olov Wallner, Sarah Müller, Therese Pham, Camilla Göktürk, Azita Rasti, Sharda Suman, Raúl Torres-Ruiz, Antonio Sarno, Elisée Wiita , Evert J Homan, Stella Karsten, Karthick Marimuthu, Maurice Michel, Tobias Koolmeister, Martin Scobie, Olga Loseva, Ingrid Almlöf, Judith Edda Unterlass, Aleksandra Pettke, Johan Boström, Monica Pandey, Helge Gad, Patrick Herr, Ann-Sofie Jemth, Samir El Andaloussi, Christina Kalderén, Sandra Rodriguez-Perales, Javier Benítez, Hans Krokan, Mikael Altun, Pål Stenmark, Ulrika Warpman Berglund and Thomas Helleday. Targeting OGG1 arrests cancer cell proliferation by inducing replication stress. Nucleic Acids Res . 2020 Nov 19 doi: 10.1093/nar/gkaa1048. Online ahead of print. https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkaa1048/5992293
(15) Vasileiou PVS, Evangelou K, Vlasis K, Fildisis G, Panayiotidis MI, Chronopoulos E, Passias PG, Kouloukoussa M, Gorgoulis VG, Havaki S. Mitochondrial Homeostasis and Cellular Senescence. Cells. 2019 Jul 6;8(7):686.https://doi.org/10.3390/cells8070686
(14) Koutsoudaki PN, Papadopoulos D, Passias PG, Koutsoudaki P, Gorgoulis VG. Cellular senescence and failure of myelin repair in multiple sclerosis. Mech Ageing Dev. 2020 Dec;192:111366. https://doi.org/10.1016/j.mad.2020.111366
(13) Sakellaropoulos T, Vougas K, Narang S, Koinis F, Kotsinas A, Polyzos A, Moss TJ, Piha-Paul S, Zhou H, Kardala E, Damianidou E, Alexopoulos LG, Aifantis I, Townsend PA, Panayiotidis MI, Sfikakis P, Bartek J, Fitzgerald RC, Thanos D, Mills Shaw KR, Petty R, Tsirigos A, Gorgoulis VG. A Deep Learning Framework for Predicting Response to Therapy in Cancer. Cell Rep. 2019 Dec 10;29(11):3367-3373.e4. https://doi.org/10.1016/j.celrep.2019.11.017
(12) Gorgoulis VG, Pefani DE, Pateras IS, Trougakos IP. Integrating the DNA damage and protein stress responses during cancer development and treatment. J Pathol. 2018 Sep;246(1):12-40. https://doi.org/10.1002/path.5097
(11) Myrianthopoulos V, Evangelou K, Vasileiou PVS, Cooks T, Vassilakopoulos TP, Pangalis GA, Kouloukoussa M, Kittas C, Georgakilas AG, Gorgoulis VG. (2019) Senescence and senotherapeutics: a new field in cancer therapy. Pharmacol Ther. 2019 Jan; 193:31-49. https://doi.org/10.1016/j.pharmthera.2018.08.006
(10) Bishoy M. F. Hanna, Thomas Helleday, Oliver Mortusewicz (2020). OGG1 Inhibitor TH5487 Alters OGG1 Chromatin Dynamics and Prevents Incisions. Biomolecules 10 (11), 1483. https://doi.org/10.3390/biom10111483
(9)Timo Reisländer, Florian J.Groelly & Madalena Tarsounas (2020) Review: DNA Damage and Cancer Immunotherapy: a STING in the Tale. Molecular Cell, Available online 17 August 2020, In Press. https://doi.org/10.1016/j.molcel.2020.07.0
(8) Reihaneh Zarrizi, Martin R Higgs, Karolin Voßgröne, Maria Rossing , Birgitte Bertelsen, Muthiah Bose , Arne Nedergaard Kousholt, Heike Rösner, The Complexo Network, Bent Ejlertsen, Grant S Stewart, Finn Cilius Nielsen, Claus S Sørensen (2020). Germline RBBP8 variants associated with early-onset breast cancer compromise replication fork stability . J Clin Invest , Aug 3;130(8): 4069-4080. Doi: 10.1172/JCI127521
(7)Timo Reisländer, Emilia Puig Lombardi, Florian J. Groelly, Ana Miar, Manuela Porru, Serena Di Vito, Benjamin Wright, Helen Lockstone, Annamaria Biroccio, Adrian Harris, Arturo Londono & Madalena Tarsounas (2019). BRCA2 abrogation triggers innate immune responses potentiated by treatment with PARP inhibitors. Nat Commun 10, 3143. DOI: 10.1038/s41467-019-11048-5
(6) Eliana MC Tacconi, Sophie Badie, Giuliana De Gregoriis, Timo Reisländer, Xianning Lai, Manuela Porru, Cecilia Folio, John Moore, Arnaud Kopp, Júlia Baguña Torres, Deborah Sneddon, Marcus Green, Simon Dedic, Jonathan W Lee, Ankita Sati Batra, Oscar M Rueda, Alejandra Bruna, Carlo Leonetti, Carlos Caldas, Bart Cornelissen, Laurent Brino, Anderson Ryan, Annamaria Biroccio & Madalena Tarsounas (2019). Chlorambucil targets BRCA1/2-deficient tumours and counteracts PARP inhibitor resistance. EMBO Mol Med 11, e9982. https://doi.org/10.15252/emmm.201809982
(5) Torkild Visnes, Maurice Grube, Bishoy Magdy Fekry Hanna, Carlos Benitez-Buelga, Armando Cázares-Körner and Thomas Helleday (2018) Targeting BER enzymes in cancer therapy. DNA Repair, Volume 71, November 2018, Pages 118-126: https://doi.org/10.1016/j.dnarep.2018.08.015
(4) Torkild Visnes, Armando Cázares-Körner, Wenjing Hao, Olov Wallner, Geoffrey Masuyer, Olga Loseva, Oliver Mortusewicz, Elisée Wiita, Antonio Sarno, Aleksandr Manoilov, Juan Astorga-Wells, Ann-Sofie Jemth, Lang Pan, Kumar Sanjiv, Stella Karsten, Camilla Gokturk, Maurice Grube, Evert J. Homan, Bishoy M. F. Hanna, Cynthia B. J. Paulin, Therese Pham, Azita Rasti, Ulrika Warpman Berglund, Catharina von Nicolai, Carlos Benitez-Buelga, Tobias Koolmeister, Dag Ivanic, Petar Iliev, Martin Scobie, Hans E. Krokan, Pawel Baranczewski, Per Artursson, Mikael Altun, Annika Jenmalm Jensen, Christina Kalderén, Xueqing Ba, Roman A. Zubarev, Pål Stenmark, Istvan Boldogh, Thomas Helleday (2018) Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation. Science 16 Nov 2018: Vol. 362, Issue 6416, pp. 834-839. DOI: 10.1126/science.aar8048
(3) Nina M. S. Gustafsson, Katarina Färnegårdh, Nadilly Bonagas, Anna Huguet Ninou, Petra Groth, Elisee Wiita, Mattias Jönsson, Kenth Hallberg, Jemina Lehto, Rosa Pennisi, Jessica Martinsson, Carina Norström, Jessica Hollers, Johan Schultz, Martin Andersson, Natalia Markova, Petra Marttila, Baek Kim, Martin Norin, Thomas Olin & Thomas Helleday (September 2018). Targeting PFKFB3 radiosensitizes cancer cells and suppresses homologous recombination. Nature Communications volume 9, Article number: 3872 (2018) https://doi.org/10.1038/s41467-018-06287-x
(2) Panagiotis Galanos, George Pappas, Alexander Polyzos, Athanassios Kotsinas, Ioanna Svolaki, Nickolaos N. Giakoumakis, Christina Glytsou, Ioannis S. Pateras, Umakanta Swain, Vassilis L. Souliotis, Alexandros G. Georgakilas, Nicholas Geacintov, Luca Scorrano, Claudia Lukas, Jiri Lukas, Zvi Livneh, Zoi Lygerou, Dipanjan Chowdhury, Claus Storgaard Sørensen, Jiri Bartek and Vassilis G. Gorgoulis (March 2018). Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability. Genome Biology 19:37 https://doi.org/10.1186/s13059-018-1401-9
(1) Komseli ES, Pateras IS, Krejsgaard T, Stawiski K, Rizou SV, Polyzos A, Roumelioti FM, Chiourea M, Mourkioti I, Paparouna E, Zampetidis CP, Gumeni S, Trougakos IP, Pefani DE, O’Neill E, Gagos S, Eliopoulos AG, Fendler W, Chowdhury D, Bartek J and Gorgoulis VG (2018). A prototypical non-malignant epithelial model to study genome dynamics and concurrently monitor micro-RNAs and proteins in situ during oncogene-induced senescence. BMC Genomics 19(1): 37. doi: 10.1186/s12864-017-4375-1
https://doi.org/10.1186/s13059-018-1401-9